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Zonisamide for weight loss in obese adults: a randomized controlled trial. JAMA. 2003;289:1820-1825. Gadde KM, Yonish GM, Foust MS, Wagner HR. Combination therapy of zonisamide and bupropion for weight reduction in obese women: a preliminary, randomized, open-label study. J Clin Psychiatry. 2007;68:1226-1229. Bello NT, Zahner MR. Tesofensine, a monoamine reuptake inhibitor for the treatment of obesity.